Just 20 minutes into Bayern's Tuesday night 6-1 victory over Bremen, the former Liverpool forward was substituted.
He won't participate in the competition, according to L'Equipe, delivering the defending Africa Cup of Nations champions a severe setback.
Senegal's group stage opponents include Qatar's hosts, Ecuador, and Holland.
L'Equipe reports that Mane is thought to have sustained a tendon injury and will be absent for "many weeks," giving national team coach Aliou Cisse a big dilemma only days before unveiling his World Cup roster.
After first stating that the player had suffered a blow to the tibia, his Bayern manager Julian Nagelsmann said the player would undergo an X-ray to ascertain the severity of the injury and expressed his hope that it was 'not a significant damage'
He claimed that "he took a blow to the head of his tibia." "It's never comfortable." He must undergo an X-ray. I hope everything is okay. I hope it's not a serious injury because I didn't see him after the game. But I'm not sure right now," the Bayern manager continued. We'll wait till tomorrow before providing an update.
Mane has been a thrilling player for Bayern this season after moving to Germany from Liverpool for £35 million. In 23 games in all competitions, he has 11 goals and four assists.
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